| Monitoring Spatial Distribution of Therapeutic Substances in the Brain |
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Institute : National Institute of Neurological Disorders and Stroke (NINDS)
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| Description of Technology/Invention :
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The National Institute of Neurological Disorders and Stroke (NINDS) seeks a Cooperative Research and Development Agreement (CRADA) Collaborator to work with NINDS in the development and commercialization of surrogate markers for monitoring the spatial distribution of therapeutic substances by MRI or CT that have been administered to tissue of the brain using Convection Enhanced Delivery (CED). The macromolecular imaging agents have clearance properties that mimic the pharmacokinetic properties of co-administrated drugs, so as to be useful in quantifying the range and dosage level of therapeutic drugs using MR imaging.
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| Potential Areas of Application : |
| Delivery of various therapeutic compounds that otherwise would not pass the blood brain barrier. |
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| Main Advantages of Technology/Invention
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• Increases the breadth of compounds available for treatment of diseases and disorders of the brain.
• Improves the utilization of CED in delivering drugs to the brain
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| Current State of Development : |
• CED in use by multiple research and medical facilities
• PCT patent application filed
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| Patent Status : |
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| NIH Reference Number: |
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| Contact Information : |
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| Last Updated: 8/8/2006 |
