| Methods for Preventing Strokes by Inducing Tolerance to E-selectin |
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Institute : National Institute of Neurological Disorders and Stroke (NINDS)
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| Description of Invention : |
The expression of E-selectin is induced on human endothelium in response to activation by cytokines IL-1 and TNF. E-selectin mediates the adhesion of various leukocytes, including neutrophils, monocytes, eosinophils, natural killer cells, and a subset of T cells to activated endothelium. Activation of vascular endothelial cells by proinflammatory cytokines is believed to be involved in conversion of the luminal surface of endothelium from anticoagulant and anti-inflammatory to procoagulant and pro-inflammatory leading to thrombosis. Recently, a new method and pharmaceutical formulation have been found that induce tolerance mucosally, such as by intranasal administration. The potential of mucosally administered antigens to inhibit immune responses in an antigen specific fashion has encouraged attempts to apply these routes to counteract immune dysfunctions such as allergies and in particular, autoimmune disease. Intranasal administration of E-selectin induces tolerance to E-selectin and leads to immune-deviation of a subset of lymphocytes such that they can suppress activation of vessel segments that are beginning to express E-selectin. Production of immunosuppression via antigen-specific modulation of the immune response (mucosal tolerance) should have no systemic immunosuppressive effects.
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| Inventors : |
John M. Hallenbeck et al. |
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| Patent Status : |
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| NIH Reference Number: |
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| Portfolios : |
Internal Medicine-Therapeutics-Anti-Inflammatory (including Autoimmune)
Internal Medicine-Therapeutics
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| For Additional Information Please Contact: |
| Norbert J. Pontzer JD PhD, Office of Technology Transfer |
| Phone: (301)435-5502 |
Email: pontzern@mail.nih.gov
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| For Additional Information Regarding Collaboration
with the Investigator Please Contact: |
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| Last Updated: 7/20/2006 |
