| The Application Of Induction Tolerance By Oral Feeding Of Myelin Basic Protein To The Generation Of Increased Resistance To Stroke |
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Institute : National Institute of Neurological Disorders and Stroke (NINDS)
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| Description of Invention : |
In vivo experiments have shown that immunosuppression in the brain can be achieved through oral tolerance to myelin basic protein (MBP). Following exposure to MBP, immune cells are relatively unreactive if they encounter MBP again which has the effect of suppressing the inflammatory reaction associated with stroke. This possible new means of minimizing the severity of damage from stroke, the number three killer of Americans and leading cause of disability, does not result in detrimental systemic side effects as other immunosuppressive agents do. This treatment could be administered to those considered at significantly increased risk for a stroke including those with a previous stroke, diabetes mellitus, hypertension, hypercholesteremia, or a history of smoking as well as those undergoing a medical or surgical treatment which increases the possibility of an ischemic event.
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| Inventors : |
KJ Becker, John Hallenbeck |
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| Patent Status : |
U.S. Patent 6,068,844 issued 30 May 2000 |
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| NIH Reference Number: |
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| Portfolios : |
Central Nervous System -Therapeutics-Neurological Therapeutics-Stroke
Central Nervous System –Therapeutics
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| For Additional Information Please Contact: |
| Norbert J. Pontzer JD PhD, Office of Technology Transfer |
| Phone: (301)435-5502 |
Email: pontzern@mail.nih.gov
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| For Additional Information Regarding Collaboration
with the Investigator Please Contact: |
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| Last Updated: 7/20/2006 |
