| Efficient Generation of Midbrain Neurons from Mouse Embryonic Stem Cells |
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Institute : National Institute of Neurological Disorders and Stroke (NINDS)
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| Description of Invention : |
This technology describes a method to promote stem cell survival and proliferation by manipulating the phosphorylation state of Stat3 protein. This method has been shown to enhance survival and proliferation in stem cell cultures in vitro, and also in neuronal precursor cells in vivo. The methods include use of a Notch ligand and growth factors such as FGF-2 or insulin to promote neural stem cell survival and proliferation. The technology is also directed to a population of stem cells expressing STAT3 phosphorylated at serine 727.
Applications:
• Clinical treatment for stroke and other neurodegenerative diseases by administration of agents that promote stem cell survival and proliferation
• Increased generation of stem cells in vitro
• Screening assays for agents that promote proliferation of stem cells or inhibit proliferation of cancer cells
• Diagnostic assay for cancer to determine the phosphorylation state of the protein in tumors
Market:
• Treatment for neurological disorders such as Parkinson’s disease or stroke
• Prognostic marker to help determine response of individuals with cancer
• Commercial suppliers or large-scale users of stem cells
Development Status:
A method of increasing proliferation and survival of stem cells or precursor cells in vitro has been developed. The cells produced by this method have been described in an article in Nature 2006 Aug 17;442(7104):823-826.
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| Inventors : |
| Andreas Androutsellis-Theotokis and Ronald D.G. McKay (NINDS) |
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| Patent Status : |
| U.S. Provisional Application No. 60/715,935 filed 08 Sep 2005 |
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| NIH Reference Number: |
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| Portfolios : |
Devices/Instrumentation-Diagnostics-Methods
Devices/Instrumentation-Diagnostics
Internal Medicine-Diagnostics
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| For Additional Information Please Contact: |
| Fatima Sayyid, M.H.P.M, Office of Technology Transfer |
| Phone: 301/435-4521 |
Email: sayyidf@mail.nih.gov
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| For Additional Information Regarding Collaboration
with the Investigator Please Contact: |
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| Last Updated: 3/26/2009 |
