| Methods and Materials for Controlling Stem Cell and Cancer Cell Proliferation and Differentiation |
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Institute : National Institute of Neurological Disorders and Stroke (NINDS)
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| Description of Invention : |
Regenerative medicine has the potential to treat numerous human diseases and afflictions including neurodegenerative disorders and spinal cord injury that are typically insidious and worsen over time. This technology consists of a promising treatment method that coaxes stem cells into a state that promotes survival and proliferation. Two critical elements of this approach involve identifying the target niche and determining the pharmacological agents that can be used to promote stem cell regeneration.
Specifically, this technology consists of a method to activate the endogenous neural stem cells (NSCs) to promote their survival and yield using angiopoietin-2 and a cocktail of ligands and growth factors. This method has demonstrated that it can significantly improve the yield of stem cell cultures in vitro and stimulate behavioral recovery in a model of Parkinson’s disease in vivo. This method is applicable to a variety of stem cell types including embryonic stem cells, adult spinal cord cells, and pericyctes from blood vessels.
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| Inventors : |
| Andreas Androutsellis-Theotokis and Ronald D.G. McKay (NINDS) |
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| Patent Status : |
U.S. Provisional Application No. 60/965,094 filed 16 Aug 2007 (HHS Reference No. E-182-2007/0-US-01)
Patent Status: Pending
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| Last Updated: 3/26/2009 |
